Methyl factors
Methyl factors

Methyl factors

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Improved Methyl Factors has been developed to help support those who need extra nutrients to facilitate the methylation process in the body. 100mg of vitamin B1 in the form of benfotiamine has been added to improve the formula. Benfotiamine is lipid-soluble (so is more bioavailable and effective than thiamine) making it potentially better suited to those who smoke or drink alcohol. Benfotiamine is also a potent antioxidant and essential for energy metabolism.

Methyl Factors also contains TMG (Trimethylglycine) known as betaine, vitamin B6 (as pyridoxal-5-phosphate), folic acid (as L-Methylfolate), vitamin B12 as methylcobalamin and vitamin B2 (riboflavin 5-phosphate) - all of these nutrients can donate methyl groups. The mineral zinc is also included in the formula. All of these ingredients also support the nervous system and detoxification pathways in the body. Only recommended for use under the guidance of a practitioner.

  • TMG, vitamin B6, vitamin B12 and methylfolate collectively provide a full spectrum of methyl donor nutrients
  • TMG is the best methyl donor. It is not the same as betaine HCL, which is not necessarily a methyl donor but is sometimes used erroneously for this purpose. Many diets are low in betaine from food sources
  • B vitamin deficiency is all too common, and this is another reason for shortage of methyl donor nutrients in diet
  • Zinc has been added to help protect and support those who drink alcohol regularly
  • This formula comprises folic acid as methylfolate as it is the most stable, safe and bio-effective supplemental form of folate and the only form useful to people with impaired methylation
  • This formula includes vitamin B6 in the form of pyridoxal-5-phosphate, the bio-active and enzymatically converted form of B6. There is evidence to show that some people with high homocysteine, for instance, and impaired methylation, lack the enzyme necessary to convert pyridoxine (the other supplement form of B6) to its metabolically active form
  • This supplement includes vitamin B12 as methylcobalamin, the most bio-effective form. Some vitamin B12 products on the market are cyanocobalamin which needs to be enzymatically converted to methylcobalamin in the body
  • Folate, vitamin B12, betaine and vitamin B6 all have the permitted health claim of ‘contributing to normal homocysteine metabolism’ 


Methyl Factors 1 capsule will provide on average:
Active Nutrient Strength %NRV*
Vitamin B1 (as benfotiamine) 100.0mg 9090
Trimethylglycine 400.0mg *
Vitamin B2 (riboflavin 5-phosphate) 3mg 214
Vitamin B6 (as pyridoxal-5-phosphate) 15mg 1071
Folic Acid (as methylfolate) 800µg 400
Vitamin B12 (as methylcobalamin) 1000µg 40,000
Zinc 5mg 50
+NRV = Nutritional Reference Value
* Indicates no NRV